metaflumizone (bsi, pa iso)
Metaflumizone
CAS: 139968-49-3
Molecular Formula: C24H16F6N4O2
metaflumizone (bsi, pa iso) - Names and Identifiers
| Name | Metaflumizone |
| Synonyms | BAS3201 bas 320i Metaflumizone METAFLUMIZONE Metaflumizone [iso] metaflumizone (bsi, pa iso) 2μ-[2-(4-Cyanophenyl)-1-(α,α,α-trifluoro-m-tolyl)ethylidene]-4-(trifluoromethoxy)carbanilohydrazide 2-[2-(4-Cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(trifluoromethoxy)phenyl]-hydrazinecarboxamide Hydrazinecarboxamide,2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(trifluoromethoxy)phenyl]- (2E)-2-{2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene}-N-[4-(trifluoromethoxy)phenyl]hydrazinecarboxamide |
| CAS | 139968-49-3 |
| EINECS | 204-798-3 |
| InChI | InChI=1/C24H16F6N4O2/c25-23(26,27)18-3-1-2-17(13-18)21(12-15-4-6-16(14-31)7-5-15)33-34-22(35)32-19-8-10-20(11-9-19)36-24(28,29)30/h1-11,13H,12H2,(H2,32,34,35)/b33-21+ |
| InChIKey | MIFOMMKAVSCNKQ-QNKGDIEWSA-N |
metaflumizone (bsi, pa iso) - Physico-chemical Properties
| Molecular Formula | C24H16F6N4O2 |
| Molar Mass | 506.4 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Appearance | neat |
| pKa | 10.82±0.46(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.547 |
| In vitro study | Metaflumizone (10 μM) completely inhibits the Para/TipE sodium currents in Xenopus oocytes. |
metaflumizone (bsi, pa iso) - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
| RTECS | MV1576452 |
| Toxicity | 氰氟虫腙原药大鼠急性经口LD 蚰 ( M，F)>5000Hl g 唱b.w、急性 经皮L D。(M，F )> 5 0 00 m g/k g b .W、急性吸入 L C。(M，F)>5.2 m g/L，对兔眼睛、皮肤无刺激性，对猪皮肤无致敏性；对哺乳动物无神经毒性、A m es试验呈阴性；鹌鹑经 ElL D ~>2000 m g/kg、蜜蜂经E I L D ~> 106 m g/只蜜蜂( 48 h)、鲑鱼LC o>343 ng/g(96 h)，氰氟虫腙对鸟类的急性毒性低，对蜜蜂低危险， 由于在水中能迅速地水解和光解，对水生生物无实际危害。 |
metaflumizone (bsi, pa iso) - Reference Information
| pharmacological effects | cyanofluoride is a new mechanism of action of pesticides, by attaching to the receptor of the sodium ion channel, the passage of sodium ions is blocked, and there is no interaction resistance with the compound of the pyrethroid ester or other kind. The drug is mainly through the feeding of pests into the body of gastric poison to kill pests, contact killing effect is small, no absorption effect. The drug has a good control effect on the target pests and larvae of each age. After the insects eat, the drug enters the worm, and blocks the sodium ion channel on the axon membrane of the insect neuron through a unique mechanism of action, so that sodium ions can not pass through the axon membrane, thereby inhibiting the nerve Impulse to excessive relaxation of the worm, paralysis, a few hours later, the pest is stopped feeding, 1~3 d death. |
| toxicity | rat acute oral LD (M,F)>5000Hl g B. w, acute percutaneous L D. (M,F )> 50 00 m g/k g B. W, acute inhalation L C. (M,F)>5.2 m g/L, no irritation to rabbit eyes and skin, no sensitization to pig skin; No neurotoxicity to mammals, A m es test was negative; quail through ElL D ~>2000 m g/kg, bee through E I L D ~> 106 m g/Bee (48 h), salmon LC o>343 ng/g(96 h), low acute toxicity to birds, low risk to bees, due to rapid hydrolysis and Photolysis in water, no actual harm to aquatic organisms. |
| biological activity | Metaflumizone is a semicarbazide insecticide that is an effective sodium channel blocker. |
| Target | Sodium channel |
| in vitro study | Metaflumizone (10 μm) complete inhibit the Para/tic sodium current in Xenopus oocytes. |
| EPA chemical substance information | information is provided by: ofmpeb.epa.gov (external link) |
Last Update：2024-04-10 22:29:15
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